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Although assessment of OZ439 in phase clinical trials has highlighted formulation challenges associated with this compound, substantial investment continues in next-generation ozonides and reformulated OZ439-adjacent chemotypes with improved pharmacokinetic and pharmacodynamic properties are being developed ( 45–48 )

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Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance